orphan nuclear receptor NR6A1 (nuclear receptor subfamily 6 group A member 1, germ cell nuclear factor, GCNF, retinoid receptor-related testis-specific receptor, RTR, NR6A1, GCNF)

Function

• orphan nuclear receptor
• binds to a response element containing the sequence 5'-TCAAGGTCA-3'
• may be involved in regulation of gene expression in germ cell development during gametogenesis
• interacts with RXRIP110

Structure

• homodimer
• belongs to the nuclear hormone receptor family, NR6 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

highest expression in germ cells of adult testis

More general terms

• orphan receptor
• nuclear hormone receptor family
• zinc finger protein
• testis-specific protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2649
• OMIM: https://mirror.omim.org/entry/602778
• UniProt: http://www.uniprot.org/uniprot/Q15406.html