retinoid X receptor-interacting protein 110; BRCA1-A complex subunit RAP80; receptor-associated protein 80; ubiquitin interaction motif-containing protein 1 (UIMC1, RAP80, RXRIP110)

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Function

Structure

  • the UIM-linker region between the 2 UIM repeats determines selectivity for Lys-63-linked ubiquitin
    • the length of the linker is important
    • the linker reduces the flexibility between the UIM repeats & promotes high-affinity & linkage-selective interactions
  • the Abraxas-interacting region (AIR) mediates interaction with FAM175A/Abraxas
  • belongs to the RAP80 family
  • contains 2 UIM (ubiquitin-interacting motif) repeats

Compartment

Alternative splicing

named isoforms=5

Expression

More general terms

Additional terms

Component of

References

Database