BRCA1-associated RING domain protein 1 (BARD1)
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Function
- binds to BRCA1 & may be involved in mediating tumor suppression by BRCA1
- interacts with 50 kD subunit of cleavage stimulation factor (CSTF1) & inhibits polyadenylation
- interacts with RNA polymerase 2
- inhibits pre-mRNA 3' cleavage in vitro
- putative role in the cellular response to DNA damage
- processed during apoptosis
- the homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer
- preferentially forms heterodimers with BRCA1
- can also form heterodimers with CSTF-50
Structure
- homo- & heterodimer
- contains 3 ANK repeats
- contains 2 BRCT domains
- contains 1 RING-type Zn+2 finger
Compartment
- nucleus
- during S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci
- can translocate to the cytoplasm
Pathology
- defects in BARD1 gene are found in primary breast cancer, ovarian cancer & uterine cancer
More general terms
References
- ↑ Wu LC et al. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nature Genetics 14:430-40 1996 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8944023
- ↑ Kleiman FE & Manley JL Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 Science 285:1576-9 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10477523
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=580
- ↑ Atlas of genetics & cytogenetics in oncology & Haematology http://atlasgeneticsoncology.org/genes/BARD1ID756ch2q35.html
- ↑ UniProt http://www.uniprot.org/uniprot/Q99728.html