Notch/ankyrin repeat

^[1]^[2]^[3]^[4]

Introduction

Tandemly repeated module of about 33 amino acid residues origionally identified as a site anchoring ankyrin to tubulin. It is present in transmembrane receptors, cytoskeletal proteins & transcription factors. It mediates protein-protein interactions crucial for intercellular signalling (4).

↑ Thompson CC, Brown TA, McKnight SL. Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex. Science. 1991 Aug 16;253(5021):762-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1876833
↑ LaMarco K, Thompson CC, Byers BP, Walton EM, McKnight SL. Identification of Ets- and notch-related subunits in GA binding protein. Science. 1991 Aug 16;253(5021):789-92. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1876836
↑ Hoffman M. New role found for a common protein "motif". Science. 1991 Aug 16;253(5021):742. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1831563
↑ Pawson T Protein modules and signalling networks Nature 373:573 1995 (Notch) PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822