cleavage stimulation factor 50 kD subunit; CSTF 50 kD subunit; CF-1 50 kD subunit; CstF-50 (CSTF1)

Function

• one of the multiple factors required for polyadenylation & 3'-end cleavage of mammalian pre-mRNAs
• may be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA
• component of the CSTF complex
• interacts directly with CSTF3
• interacts with BARD1

Structure

• the N-terminus is blocked
• homodimer
• N-terminus mediates homodimerization
• contains 6 WD repeats
• the WD6 domain is required for interaction with BARD1
• WD domains are responsible for interaction with CSTF3

Compartment

nucleus

More general terms

• RNA-binding protein
• protein subunit
• nuclear protein
• WD repeat protein family
• phosphoprotein

Component of

• cleavage stimulation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1477
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1477
• OMIM: https://mirror.omim.org/entry/600369
• UniProt: http://www.uniprot.org/uniprot/Q05048.html