estrogen receptor-1; estrogen receptor-alpha; ER; estradiol receptor; ER-alpha; nuclear receptor subfamily 3 group A member 1 (ESR1, ESR, NR3A1)
Jump to navigation
Jump to search
Function
- nuclear hormone receptor
- cytoplasmic anchoring &/or assembly associated with heat shock proteins hsp70 & hsp90 & immunophilin p59FKBP
- interacts with SLC30A9 (putative)
- binds DNA as a homodimer
- can form a heterodimer with ESR2
- interacts with NCOA3, NCOA5 & NCOA6 coactivators, leading to a strong increase of transcription of target genes
- interacts with NCOA7 in a ligand-inducible manner
- interacts with PHB2, PELP1 & UBE1C
- interacts with AKAP13
- interacts with CUEDC2
- interacts with JARID1A
- interacts with SMARD1
- interacts with HEXIM1 & MAP1S
- interacts with PBXIP1
- interaction with MUC1 is stimulated by 17 beta-estradiol (E2) & enhances ERS1-mediated transcription
- interacts with DNTTIP2 & FAM120B
- interacts with isoform 4 of TXNRD1
- interacts with MLL2
- interacts with ATAD2; interaction enhanced by estradiol
- phosphorylated by cyclin A/CDK2
- phosphorylation probably enhances transcriptional activity
Structure
- glycosylated; contains N-acetylglucosamine, probably O-linked
- composed of three domains: a modulating N-terminal domain, a DNA-binding domain & a C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR3 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment
Alternative splicing
named isoforms=2
Expression
- breast
- bone
- reproductive organs
- liver[3]
- brain[3]
- cardiovascular system[3]
Polymorphism
- genetic variations in ESR1 are correlated with bone mineral density (BMD)
More general terms
Additional terms
References
- ↑ Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 704
- ↑ Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
- ↑ 3.0 3.1 3.2 3.3 Journal Watch 22(5):39, 2002 Zhu Y et al, Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science. 2002 Jan 18;295(5554):505-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11799247
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2099
- ↑ Uniprot http://www.uniprot.org/uniprot/P03372.html
- ↑ Wikipedia; Note: estrogen receptor entry http://en.wikipedia.org/wiki/estrogen_receptor