nuclear receptor coactivator 5; NCoA-5; coactivator independent of AF-2; CIA (NCOA5 KIAA1637)

Function

• nuclear receptor coregulator
• can have both coactivator & corepressor functions
• interacts with steroid receptors (ESR1 & ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, & with the orphan nuclear receptor NR1D2
• role in coactivation of nuclear steroid receptors (ER) as well as corepression of MYC in response to 17-beta-estradiol (E2)
• binds HTATIP2/TIP30
• interacts with YLPM1
• forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX & PPP1CA

Structure

• contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif essential for association with nuclear receptors

Compartment

nucleus

Expression

widely expressed

More general terms

• nuclear (steroid) receptor coactivator (NRC, SRC, NCoA)
• phosphoprotein

Additional terms

• nuclear hormone receptor family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57727
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57727
• UniProt: http://www.uniprot.org/uniprot/Q9HCD5.html