orphan nuclear receptor NR1D2; nuclear receptor subfamily 1 group D member 2; Rev-erb-beta; EAR-1R; rev-erbA-alpha-related receptor; orphan nuclear hormone receptor BD73; rev-erb (NR1D2, RVR)

Function

• binds to the sequences 5'-AATGTAGGTCA-3' & 5'-ATAACTAGGTCA-3'
• potent competitive repressor of ROR alpha
• interacts with NCOA5 coactivator, increasing transcription of target genes

Structure

• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus

Comparative biology

• activation of Rev-erb with SR9009 led to increased metabolic activity in skeletal muscle of mice
  • treated mice had a 50% increase in running time & distance

More general terms

• orphan receptor
• nuclear hormone receptor family
• zinc finger protein

Additional terms

• nuclear receptor subfamily 1 group D member 1; Rev-erbA-alpha; V-erbA-related protein 1; EAR-1 (NR1D1, EAR1, HREV, THRAL)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9975
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9975
• OMIM: https://mirror.omim.org/entry/602304
• UniProt: http://www.uniprot.org/uniprot/Q14995.html