nuclear receptor ROR-alpha; retinoid-related orphan receptor-alpha; nuclear receptor RZR-alpha; nuclear receptor subfamily 1 group F member 1 (RORA, NR1F1, RZRA)

Function

• orphan nuclear receptor
• binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence
• one isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'

Structure

• monomer
• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=4; alpha-1,2,3,4

More general terms

• nuclear hormone receptor NR1 subfamily
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6095
• OMIM: https://mirror.omim.org/entry/600825
• UniProt: http://www.uniprot.org/uniprot/P35398.html