nuclear receptor subfamily 1 group D member 1; Rev-erbA-alpha; V-erbA-related protein 1; EAR-1 (NR1D1, EAR1, HREV, THRAL)

Function

• constitutive transcriptional repressor
• possible receptor for triiodothyronine
• interacts with C1D (putative)

Structure

• composed of 3 domains:
  • modulating N-terminal domain
  • DNA-binding domain
  • C-terminal steroid-binding domain
• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus (putative)

Expression

• expressed in all tissues & cell lines examined

Pathology

• expressed at high levels in some squamous carcinoma cell lines

More general terms

• nuclear hormone receptor NR1 subfamily
• zinc finger protein
• receptor
• phosphoprotein

Additional terms

• orphan nuclear receptor NR1D2; nuclear receptor subfamily 1 group D member 2; Rev-erb-beta; EAR-1R; rev-erbA-alpha-related receptor; orphan nuclear hormone receptor BD73; rev-erb (NR1D2, RVR)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9572
• OMIM: https://mirror.omim.org/entry/602408
• UniProt: http://www.uniprot.org/uniprot/P20393.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9572