nuclear DNA-binding protein C1D (hC1D, C1D)

Function

• plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA
• forms a multi-subunit complex with MPP6 & EXOSC10 & this complex along with MTR4 is required for the 3'-5' end processing of the 5.8S rRNA
• can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA
• can induce apoptosis in a TP53/p53 dependent manner
• may regulate the TRAX/TSN complex formation
• potentiates transcriptional repression by NR1D1 & THRB (putative)
• phosphorylated by PRKDC

Structure

• monomer & homodimer
• interacts with NR1D1, THRA, THRB, NCOR1 & NCOR2 (putative)
• interacts with EXOSC10
• forms a heterotrimeric complex with EXOSC10 & MPP6 in vitro
• homodimeric form interacts with TSNAX following gamma-radiation
• interacts with RAC3
• belongs to the C1D family

Compartment

• cytoplasm, nucleus, nucleolus
• EXOSC10 is required for nucleolar localization

Expression

• ubiquitous
• expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid & salivary gland
• expressed at high levels in the fetal; lung, liver & kidney
• expressed at low levels in skeletal muscle, appendix, heart, lung & colon
• induced by gamma-radiation

More general terms

• DNA-binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1043
• OMIM: https://mirror.omim.org/entry/606997
• UniProt: http://www.uniprot.org/uniprot/Q13901.html