translin (TSN)

Function

• DNA-binding protein
• specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments
• seems to recognize single-stranded DNA ends generated by staggered breaks occuring at recombination hot spots
• forms a multimeric ring-shaped structure
• interacts with TSNAX

Structure

belongs to the translin family

Compartment

cytoplasm. nucleus

More general terms

• DNA-binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7247
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7247
• OMIM: https://mirror.omim.org/entry/600575
• UniProt: http://www.uniprot.org/uniprot/Q15631.html