thyroid hormone receptor alpha; T3 receptor-alpha; nuclear receptor subfamily 1 group A member 1; C-erbA-alpha; c-erbA-1; EAR-7; EAR7 (THRA, ERBA1, NR1A1, THRA1, THRA2)

Function

• nuclear hormone receptor
• high affinity receptor for triiodothyronine (T3)
• interacts with NCOA3 & NCOA6 coactivators, leading to a strong increase of transcription of target genes
• probably interacts with SFPQ.
• interacts with C1D (putative)
• interacts with AKAP13

Structure

• composed of three domains:
  • modulating N-terminal domain
  • DNA-binding domain
  • C-terminal steroid-binding domain
• belongs to the nuclear hormone receptor family, NR1 subfamily
• contains 1 nuclear receptor DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=4

More general terms

• triiodothyronine [T3] receptor or erbA proto-oncogene protein
• zinc finger protein
• DNA-binding protein

More specific terms

• T3 receptor alpha-1, c-erbA alpha-1 protein or EAR-7-1
• T3 receptor alpha-2, c-erbA alpha-2 protein or EAR-7-2

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7067
• OMIM: https://mirror.omim.org/entry/190120
• UniProt: http://www.uniprot.org/uniprot/P10827.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7067