triiodothyronine [T3] receptor or erbA proto-oncogene protein

Introduction

c-erbA proto-oncogene protein or thyroid hormone receptor. Apparently 2 different genes differentially expressed in different tissues, each with at least 2 different splice forms. The receptor is not associated with hsp90, thus no cytoplasmic anchoring. It binds to DNA as heterodimer with RXR. The unoccupied receptor binds to its recognition sequence & inhibits transcription.

More general terms

• nuclear hormone receptor NR1 subfamily
• phosphoprotein
• proto oncogene protein

More specific terms

• thyroid hormone receptor alpha; T3 receptor-alpha; nuclear receptor subfamily 1 group A member 1; C-erbA-alpha; c-erbA-1; EAR-7; EAR7 (THRA, ERBA1, NR1A1, THRA1, THRA2)
• thyroid hormone receptor beta; nuclear receptor subfamily 1 group A member 2 (THRB, ERBA2, NR1A2, THR1)

Additional terms

• COP9 signalosome complex subunit 2; SGN2; signalosome subunit 2; alien homolog; JAB1-containing signalosome subunit 2; thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 (COPS2, CSN2, TRIP15)
• retinoid X receptor (RXR)
• triiodothyronine (T3, liothyronine, Cytomel)

Component of

• thyroid hormone receptor associated protein complex (TRAP)