COP9 signalosome complex subunit 2; SGN2; signalosome subunit 2; alien homolog; JAB1-containing signalosome subunit 2; thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 (COPS2, CSN2, TRIP15)

Function

• component of the COP9 signalosome complex
• in the complex, interacts directly with COPS1, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), CUL1, CUL2
• interacts with ligand binding domain of thyroid receptor
• interacts with IRF8, NR2F1, NR0B1
• interacts with NIF3L1 (putative)
• phosphorylated by CK2 & PKD kinases

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

More general terms

• other protein

Additional terms

• triiodothyronine [T3] receptor or erbA proto-oncogene protein

Component of

• COP9 signalosome complex (CSN complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9318
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9318
• OMIM: https://mirror.omim.org/entry/604508
• UniProt: http://www.uniprot.org/uniprot/P61201.html