COP9 signalosome complex subunit 6 (signalosome subunit 6, SGN6, JAB1-containing signalosome subunit 6, Vpr-interacting protein, hVIP, MOV34 homolog, COPS6, CSN6)

Function

• component of the COP9 signalosome complex
• in the complex, interacts directly with COPS2, COPS4, COPS5, COPS7 (COPS7A or COPS7B)
• interacts with translation initiation factor EIF3S6
• interacts weakly with RBX1
• although strongly related to metalloprotease proteins, it lacks the JAMM motif that probably constitutes the catalytic center

Compartment

• nucleus, cytoplasm

Expression

widely expressed

Pathology

• interaction with HIV1 Vpr protein may lead to translocation to a perinuclear region

More general terms

• protein subunit

Component of

• COP9 signalosome complex (CSN complex)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1098
• UniProt: http://www.uniprot.org/uniprot/Q7L5N1.html