COP9 signalosome complex subunit 7a (signalosome subunit 7a, SGN7a, JAB1-containing signalosome subunit 7a, COPS7a, dermal papilla-derived protein 10, JAB7a, CSN7a, DERP10)

Function

• component of the COP9 signalosome complex
• in the complex, interacts with COPS1,COPS2, COPS4, COPS5, COPS6, COPS8
• interacts with PMF1
• interacts with the translation initiation factor EIF3S6
• interacts with CK2, PKD, ID3
• phosphorylated by CK2 & PKD kinases
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the CSN7/EIF3M family, CSN7 subfamily
• contains 1 PCI domain

Compartment

cytoplasm, nucleus

Expression

• widely expressed
• expressed at high level in brain, heart, skeletal muscle

More general terms

• protein subunit
• dermal papilla-derived protein

Component of

• COP9 signalosome complex (CSN complex)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UBW8.html