DNA-binding protein inhibitor ID-3; inhibitor of DNA binding 3; ID-like protein inhibitor HLH 1R21; Helix-loop-helix protein HEIR-1 (ID3, 1R21, HEIR-1)

Function

• ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding
• ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer
• may inhibit other transcription factors
• interacts with COPS5 & COPS7A (putative)
• homodimer, & heterodimer with other HLH proteins

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Expression

• expressed abundantly in lung, kidney & adrenal gland, but not in adult brain
• induced by phorbol 12-myristate 13-acetate (PMA)

More general terms

• DNA-binding protein inhibitor; inhibitor of DNA binding (ID)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3399
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3399
• OMIM: https://mirror.omim.org/entry/600277
• UniProt: http://www.uniprot.org/uniprot/Q02535.html