COP9 signalosome complex subunit 5 (signalosome subunit 5, SGN5, Jun activation domain-binding protein 1, COPS5, JAB1)

Function

• component of the COP9 signalosome complex
• in the complex, acts as the catalytic center that mediates cleavage of Nedd8 from cullins
• no metalloprotease activity by itself, requires other subunits of the CSN complex
• interacts with other proteins regulated by the CSN complex
• JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins
  • may constitute the catalytic center of the complex

Cofactor: divalent metal ions

Structure

• JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins; it may constitute the catalytic center of the complex
• belongs to the peptidase M67A family, CSN5 subfamily
• contains 1 MPN (JAB/Mov34) domain

Compartment

cytoplasm, nucleus

More general terms

• protein subunit

Component of

• COP9 signalosome complex (CSN complex)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1098
• OMIM: https://mirror.omim.org/entry/604850
• UniProt: http://www.uniprot.org/uniprot/Q92905.html