NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)
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Function
- ubiquitin-like protein
- cell cycle control
- embryogenesis
- covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 & linkage to the E2 enzyme UBE2M
- attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity
- promotes polyubiquitination & proteasomal degradation of cyclins
- directly interacts with NUB1, AHR
- covalently attached to cullins, p53
- cleavage of precursor form by UCHL3 or SENP8 is necessary for function
Structure
belongs to the ubiquitin family
Compartment
Expression
- expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon, leukocytes
More general terms
Additional terms
- APP-binding protein 1
- cullin-associated NEDD8-dissociated protein (CAND)
- NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C)
- NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; ubiquitin-conjugating enzyme E2 M (UBE2M, UBC12)
- neural precursor cell expressed developmentally downregulated (NEDD) protein