NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; ubiquitin-conjugating enzyme E2 M (UBE2M, UBC12)

Function

• accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex & catalyzes its covalent attachment to other proteins
• the specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 & CUL4
• involved in cell proliferation
• protein modification; protein neddylation
• interacts with UBA3 & RBX1

Structure

• both the N-terminal docking peptide & the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8
• belongs to the ubiquitin-conjugating enzyme family UBC12 subfamily

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)
• phosphoprotein

Additional terms

• NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9040
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9040
• OMIM: https://mirror.omim.org/entry/603173
• UniProt: http://www.uniprot.org/uniprot/P61081.html