Cullin-2; CUL-2 (CUL2)

Function

• core component of multiple cullin-RING-based ECS complex(es)
  • the E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit & is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (putative)
• protein modification; protein ubiquitination
• CBC(VHL) complex formation seems to promote neddylation
• deneddylated via its interaction with the COP9 signalosome (CSN complex) (putative)
• component of the ECS(VHL) or CBC(VHL) complex
• component of the ECS(MED8) complex with the probable substrate recognition component MED8 (putative)
• component of the ECS(PPIL5) complex with the probable
• substrate recognition component PPIL5
• component of a probable ECS E3 ubiquitin-protein ligase complex containing CUL2, RBX1, TCEB1, TCEB2 & FEM1B.
• part of an E3 ubiquitin-protein ligase complex including ZYG11B, CUL2 & elongin BC
• part of an E3 ubiquitin-protein ligase complex including ZYG11BL, CUL2 & elongin BC.
• interacts with RBX1, RNF7, FEM1B & TIP120A/CAND1
• interacts with COPS2, & MED8 (putative)
• interacts with human respiratory syncytial virus (HRSV) protein NS1

Structure

belongs to the cullin family

More general terms

• cullin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8453
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8453
• OMIM: https://mirror.omim.org/entry/603135
• UniProt: http://www.uniprot.org/uniprot/Q13617.html