influenza virus NS1A-binding protein (NS1-binding protein, NS1-BP, aryl hydrocarbon receptor-associated protein 3, IVNS1ABP, ARA3, FLARA3, KIAA0850, NS1, NS1BP, HSPC068)
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Function
- role in cell division & in dynamic organization of actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats
- protects cells from cell death induced by actin destabilization
- protects neurons from dendritic spines & actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed
- activates Erk signaling pathway when overexpressed in cultured cell lines
- may be a component of cellular splicing machinery
- role in pre-mRNA splicing (putative)
- may mediate inhibition of splicing by NS/influenza virus NS1A protein
- functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing concentration of AHR available to activate transcription
- interacts with NS/Influenza virus NS1A protein & with aryl hydrocarbon receptor (AHR)
Structure
- homodimer, through the BTB domain
- contains 1 BACK domain (BTB/Kelch associated domain)
- contains 1 BTB domain (POZ domain), inhibits AHR signaling induced by IVNS1ABP
- contains 6 Kelch repeats
Compartment
- cytoplasm, cytoskeleton, nucleus
- associated with actin filaments
- localization related to nuclear speckle domains which correspond to interchromatin granules & are enriched in factors involved in pre-mRNA splicing
- following influenza A virus infection, redistribution from nuclear speckles to a more diffuse distribution in nucleoplasm