aryl hydrocarbon receptor; Ah receptor; AhR; dioxin receptor (AHR)

Function

• ligand-activated transcriptional activator
• role in cell-cycle regulation
• likely to play a role in the development & maturation of many tissues
• binds to DNA as heterodimer with ARNT (Ah receptor complex)
• efficient DNA binding requires dimerization with another bHLH protein
• in the nucleus, heterodimer of AHR & ARNT
• interacts with coactivators including SRC-1, RIP140 & NOCA7, & with the corepressor SMRT
• interacts with NEDD8 & IVNS1ABP
• binds MYBBP1A (putative)
• interacts with HSP90

Structure

• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 PAC domain (PAS-associated C-terminal domain)
• contains 2 PAS domains (PER-ARNT-SIM domains)

Compartment

• cytoplasm. nucleus
• first cytoplasmic
• upon binding with ligand & interaction with a HSP90, it translocates to the nucleus

Expression

• expressed in all tissues tested, including blood, brain, heart, kidney, liver, lung, pancreas & skeletal muscle
• induced or repressed by TGF-beta & dioxin (cell-type specific)
• repressed by cAMP, retinoic acid, & TPA

Pharmacology

• aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

More general terms

• basic helix loop helix (bHLH) family transcription factor

Additional terms

• 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin TCDD)
• AH receptor-interacting protein; AIP; aryl-hydrocarbon receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2; XAP-2 (AIP, XAP2)
• aryl hydrocarbon [Ah] receptor complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:196
• OMIM: https://mirror.omim.org/entry/600253
• UniProt: http://www.uniprot.org/uniprot/P35869.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=196