aryl hydrocarbon [Ah] receptor complex

Function

• binds to the XRE promoter region of genes it activates
• activates expression of multiple phase I & II xenobiotic chemical metabolizing enzyme genes including CYP1A1 gene
• mediates biochemical & toxic effects of halogenated aromatic hydrocarbons
• role in cell-cycle regulation
• likely to play a role in the development & maturation of many tissues

Structure

• heterodimer of AHR & ARNT

More general terms

• molecular complex