aryl hydrocarbon receptor nuclear translocator; ARNT protein; class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta (ARNT, BHLHE2)

Introduction

See Ah receptor complex

Function

• Ah receptor binds to DNA as heterodimer with ARNT
• required for activity of the Ah (dioxin) receptor
• required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding
• the complex then initiates transcription of genes involved in activation of PAH procarcinogens
• heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia
• efficient DNA binding requires dimerization with another bHLH protein
• forms a heterodimer with AHR, AHRR, HIF1A & EPAS1/HIF2A as well as with other bHLH proteins
• interacts with TACC3 (putative)
• interacts with NOCA7
• heterodimer with HIF1A

Structure

• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 PAC (PAS-associated C-terminal) domain
• contains 2 PAS (PER-ARNT-SIM) domains

Compartment

nucleus

Alternative splicing

named isoforms=3

More general terms

• basic helix loop helix (bHLH) family transcription factor
• phosphoprotein

Additional terms

• aromatic hydrocarbon
• aryl hydrocarbon [Ah] receptor complex
• hypoxia inducible factor 1

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=405
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:405
• OMIM: https://mirror.omim.org/entry/126110
• UniProt: http://www.uniprot.org/uniprot/P27540.html