hypoxia-inducible factor 2 alpha; endothelial PAS domain protein 1; EPAS-1; member of PAS protein 2; MOP2; HIF-2 alpha; HIF-1 alpha-like factor (HIF2A,HLF)

Function

• binds to hypoxia response element (HRE) of target gene promoters
• regulates vascular endothelial growth factor (VEGF) expression
• implicated in the development of blood vessels
• may also play a role in the formation of the endothelium that gives rise to the blood brain barrier
• potent activator of the Tie-2 tyrosine kinase expression

Expression

• expressed in most tissues
• highest levels in placenta, lung & heart
• selectively expressed in endothelial cells

Pharmacology

• target of belzutifan (Welireg) for treatment of cancers associated with von Hippel-Lindau disease

More general terms

• basic helix loop helix (bHLH) family transcription factor
• phosphoprotein

Component of

• hypoxia inducible factor 2

Database

• OMIM: https://mirror.omim.org/entry/603349
• UniProt: http://www.uniprot.org/uniprot/Q99814.html