hypoxia-inducible factor 1 alpha; ARNT interacting protein; member of PAS protein 1 (HIF1A, MOP1)

Function

• in hypoxia, complexes with aryl hydrocarbon receptor nuclear translocation factor
• translocates to nucleus & binds to HRE elements in promoter regions of genes
• in normal conditions, HIF1-alpha is bound to VHL protein in the presence of oxygen resulting in HIF1-alpha becoming ubiquitinated & targeted to proteasomes
• HIF1-alpha is regulated by
  • prolyl hydroxylase
  • 2-oxoglutarate

Compartment

nucleus, cytoplasm

Pathology

• histologically, increased levels of HIF1-alpha was associated with poorer prognosis & resistance to therapy in head & neck cancers
• overexpression of HIF1-alpha was seen in
  • colon carcinoma
  • breast cancer
  • gastric cancer
  • esophageal cancer
  • lung carcinoma
  • skin cancer
  • ovarian cancer
  • pancreatic cancer
  • prostate cancer
  • renal carcinomas
• associated with cell proliferation

More general terms

• basic helix loop helix (bHLH) family transcription factor

Component of

• hypoxia inducible factor 1

Database

• OMIM: https://mirror.omim.org/entry/603348
• UniProt: http://www.uniprot.org/uniprot/Q16665.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3091