prolyl-4-hydroxylase; proline hydroxylase; protocollagen prolyl hydroxylase; proline, 2-oxoglutarate dioxygenase

Function

• catalyzes post-translational formation of 4-hydroxyproline in -Xaa-Pro-gly- sequences in collagens & other proteins

procollagen L-proline + 2-oxoglutarate + O2
                    <-->
procollagen trans-4-hydroxy-L-proline + succinate + CO2

Structure

• heterotetramer of two alpha-2 chains & two beta chains (the beta chain is the multi-functional PDI)

More general terms

• hydroxylase; monooxygenase
• dioxygenase
• multisubunit protein