hypoxia inducible factor 1

Function

• binds to hypoxia response elements (HREs) of target promoters in the absence of oxygen
• loss of PTEN facilitates HIF-1 mediated gene expression

Structure

• subunits HIF1A, ARNT

More general terms

• hypoxia inducible factor
• basic helix loop helix (bHLH) family transcription factor
• molecular complex

Database

• OMIM: https://mirror.omim.org/entry/606615