hypoxia inducible factor
Jump to navigation
Jump to search
Function
- trancription factors that bind to the hypoxia response elements (HREs) of target promoters in hypoxia
- regulation of erythropoietin production by the liver & kidneys
- regulated by oxygen-dependent proteasomal degradation, with a family of prolyl hydroxylases (HIF-prolyl hydroxylases) serving as oxygen sensors
More general terms
More specific terms
- hypoxia inducible factor 1
- hypoxia inducible factor 2
- hypoxia-inducible factor 3 alpha (HIF-3 alpha, HIF3 alpha 1, member of PAS protein 7, basic-helix-loop-helix-PAS protein MOP7, inhibitory PAS domain protein, IPAS, HIF3A, MOP7)
Additional terms
- hypoxia-inducible factor prolyl hydroxylase; Egl nine homolog; HIF-prolyl hydroxylase (EGLN)
- hypoxia-inducible gene 2 protein (HIG2, HILPDA, C7orf68)
References
- ↑ Chertow GM, Pergola PE, Farag YMK Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD. N Engl J Med 2021; 384:1589-1600. April 29 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33913637 https://www.nejm.org/doi/full/10.1056/NEJMoa2035938