Myb-binding protein 1A (MYBBP1A, P160)

Function

• may activate or repress transcription via interactions with sequence specific DNA-binding proteins
• transcirptional repression may be mediated (at least in part) by histone deacetylase (HDAC)
• binds to & represses JUN & MYB via the leucine zipper regions present in these proteins
• binds to & represses PPARGC1A - interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK
• binds to & stimulates transcription by AHR
• binds to KPNA2

Compartment

• cytoplasm, nucleus, nucleolus
• shuttles between the nucleus & cytoplasm
• nuclear import may be mediated by KPNA2
• nuclear export appears to depend partially on XPO1/CRM1
• predominantly nucleolar

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604885
• UniProt: http://www.uniprot.org/uniprot/Q9BQG0.html