leucine zipper
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Introduction
A periodic repetition of Leu at every 7th position over a distance covering 8 alpha-helical turns. The Leu side chains extending from one alpha-helix interact with those from a similar alpha-helix of a 2nd polypeptide, facilitating dimerization of the 2 polypeptides. The resultant structure formed by dimerization of these two regions is a coiled coil.
The leucine zipper pattern is present in many gene regulatory proteins.
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References
- ↑ prosite :accession PS00029