peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; ligand effect modulator 6 (PPARGC1A LEM6 PGC1 PGC1A PPARGC1)

Function

• transcriptional coactivator for steroid receptors & nuclear receptors
• greatly increases transcriptional activity of PPARG & thyroid hormone receptor on the uncoupling protein promoter
• can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (putative)
• binds MYBBP1A, which inhibits it transcriptional activation
• interacts with PRDM16
• interacts with LRPPRC
• homooligomer
• interacts with LPIN1 (putative)
• induction of PPARGC1A expression by exercise results in
  • secretion of irisin
  • white fat converting to brown fat
  • increased insulin receptor sensitivity

Structure

• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus

Expression

• heart, skeletal muscle, liver & kidney
• expressed at lower levels in brain & pancreas & at very low levels in the intestine & white adipose tissue
• in skeletal muscle, levels were lower in obese than in lean subjects
• fasting induces a 2-fold increase in skeletal muscle expression in obese subjects
• exercise induces skeletal muscle to produce PPARGC1A

More general terms

• transcription factor (TF)
• RNA-binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10891
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10891
• OMIM: https://mirror.omim.org/entry/604517
• UniProt: http://www.uniprot.org/uniprot/Q9UBK2.html