PR domain zinc finger protein 16; PR domain-containing protein 16; transcription factor MEL1; MDS1/EVI1-like gene 1 (PRDM16, KIAA1675, MEL1, PFM13)

Function

• binds DNA & functions as a transcriptional regulator
• role in differentiation of brown adipose tissue
• together with CEBPB, regulates differentiation of myoblastic precursors into brown adipose cells.
• repressor of TGF-beta signaling
• isoform 4 may regulate granulocyte differentiation
• interacts with CEBPA, CEBPB & CEBPD
• interaction with PPARG & PPARA controls brown adipocyte differentiation
• interaction with CTBP1 & CTBP2 represses expression of WAT-specific genes
• interaction with PPARGC1A or PPARGC1B activates transcription of BAT-specific genes
• interacts with SMAD3
• interacts with HDAC1, SKI, SMAD2 & SMAD3
  • interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes

Structure

• contains 10 C2H2-type Zn+2 fingers
• contains 1 SET domain

Compartment

nucleus

Alternative promoter usage

named isoforms=4

Expression

expressed in uterus & kidney

Pathology

• chromosomal translocation t(1;3)(p36;q21) involving PRDM16 is found in myelodysplastic syndrome (MDS) & acute myeloid leukemia (AML)
• isoform 4 is specifically expressed in adult T-cell leukemia

More general terms

• C2H2 type zinc finger protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=63976
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:63976
• OMIM: https://mirror.omim.org/entry/605557
• UniProt: http://www.uniprot.org/uniprot/Q9HAZ2.html