histone deacetylase 1 (reduced potassium dependency 3 [RPD3] homolog-like 1, HDAC1, RPD3L1)

Function

• see histone deacetylase
• part of the core histone deacetylase complex (HDAC complex)
• component of BHC histone deacetylase complex
• component of a mSin3A corepressor complex
• associates with the 9-1-1 complex
• interacts with HUS1
• found in a complex with DNMT3A & HDAC7
• interacts with BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, PCAF, PHB2, MIER1, JMJD2A/JHDM3A, MINT, NRIP1, RERE, SETDB1, SUV39H1, TGIF, TGIF2, UHRF1 & UHRF2
• interacts with the non-histone region of H2AFY. interacts with HDAC9
• interacts with BANP, CBFA2T3 & JARID1B
• interacts with SAP30L
• sumoylated on Lys-444 & Lys-476, which promotes enzymatic activity
• desumoylated by SENP1
• phosphorylation on Ser-421 & Ser-423 promotes enzymatic activity & interactions with NuRD complex & SIN3 complex

Structure

• belongs to the histone deacetylase family, type 1 subfamily

Compartment

nucleus

Expression

• ubiquitous
• expressed in heart, pancreas & testis > kidney & brain

More general terms

• histone deacetylase
• phosphoprotein

Component of

• histone deacetylase (HDAC) core complex
• BHC histone deacetylase complex

Database

• OMIM: https://mirror.omim.org/entry/601241
• UniProt: http://www.uniprot.org/uniprot/Q13547.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3065