prohibitin-2; B-cell receptor-associated protein BAP37; repressor of estrogen receptor activity; D-prohibitin (PHB2, REA, BAP)

Function

• mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (putative)
• estrogen receptor selective coregulator
  • potentiates inhibitory activities of antiestrogens
  • represses activity of estrogens
• competes with NCOA1 for modulation of estrogen receptor transcriptional activity.
• role in regulation of mitochondrial respiration activity (putative)
• role in aging vs terminal differentiation (see expression)
• interacts with PHB, ESR1, HDAC1 & HDAC5

Structure

belongs to the prohibitin family

Compartment

• mitochondrial inner membrane
• cytoplasm (putative), nucleus
• cytoplasmic & nuclear (putative)
• levels of expression in fibroblasts decrease heterogeneously during cellular aging (terminal differentiation)
• expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell cycle
• induced following inhibition of mitochondrial protein synthesis by thiamphenicol

More general terms

• mitochondrial membrane protein
• transcriptional silencer (transcriptional repressor)

Database

• UniProt: http://www.uniprot.org/uniprot/Q99623.html