prohibitin (PHB)

Function

• inhibits DNA synthesis
• role in regulating proliferation
• unclear if the protein or mRNA exhibits this effect
• role in regulating mitochondrial respiration activity
• role in terminal cellular differentiation
• interacts with PHB2

Structure

belongs to the prohibitin family

Compartment

mitochondrial inner membrane

Expression

• widely expressed in different tissues
• levels of expression in fibroblasts decrease heterogeneously during cellular terminal differentiation
• expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle
• induced following inhibition of mitochondrial protein synthesis by thiamphenicol

Pathology

mutated in sporadic breast cancer

More general terms

• nuclear protein
• phosphoprotein
• proto oncogene protein

Database

• UniProt: http://www.uniprot.org/uniprot/P35232.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5245
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5245
• OMIM: https://mirror.omim.org/entry/176705