histone deacetylase 5 (HD5, antigen NY-CO-9, HDAC5 KIAA0600)

Function

• see histone deacetylase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C
• during muscle differentiation, shuttles into the cytoplasm, allowing expression of myocyte enhancer factors
• interacts with BCOR, HDAC7, HDAC9, CTBP1, MEF2C, NCOR2, NRIP1, PHB2 & a 14-3-3 chaperone protein
• interacts with JARID1B
• phosphorylated by CaMK at Ser-259 & Ser-498
• phosphorylation is required for the export to cytoplasm
• ubiquitinated
• polyubiquitination does NOT lead to its degradation

Structure

• nuclear export sequence mediates shuttling between nucleus & the cytoplasm (putative)
• belongs to the histone deacetylase family, type 2 subfamily

Compartment

• nucleus, cytoplasm
• shuttles between the nucleus & the cytoplasm
• in muscle cells, shuttles into cytoplasm during myocyte differentiation
• export to cytoplasm depends on interaction with a 14-3-3 chaperone protein & is its phosphorylation at Ser-259 & Ser-498 by CaMK

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• histone deacetylase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UQL6.html
• OMIM: https://mirror.omim.org/entry/605315
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10014