histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Jumonji AT-rich interactive domain 1b; retinoblastoma-binding protein 2 homolog 1; RBP2-H1 (JARID1B, KDM5B, PLU1, RBBP2H1, PUT1)
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Function
- histone demethylase
- demethylates Lys-4 of histone H3, thus plays a central role in histone code
- does not demethylate histone H3 Lys-9 or H3 Lys-27
- demethylates trimethylated, dimethylated & monomethylated histone H3 Lys-4
- transcriptional corepressor for FOXG1B & PAX9
- favors proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 & HOXA5
- tumor suppressor for melanoma
- interacts with FOXG1B, PAX9, MYC, MYCN & RB1
- interacts with HDAC1, HDAC4, HDAC5 & HDAC7
Structure
- belongs to the JARID1 histone demethylase family
- contains 1 ARID domain
- contains 1 JmjC domain
- contains 1 JmjN domain
- contains 3 PHD-type zinc fingers,
- 1st 2 first PHD-type zinc finger domains are required for transcription repression activity.
- both the JmjC domain & the JmjN domain are required for enzymatic activity
Compartment
Alternative splicing
named isoforms=2
Expression
- ubiquitously expressed
- highest levels in testis
Pathology
- down-regulated in melanoma & glioblastoma
- up-regulated in breast cancer (at protein level)
More general terms
- JmjC domain-containing protein (JMJD)
- oxidoreductase
- histone demethylase
- phosphoprotein
- zinc finger protein