N-myc proto-oncogene protein (MYCN, NMYC)
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Function
- may function as a transcription factor
- efficient DNA binding requires dimerization with another bHLH protein
- binds DNA as an heterodimer with MAX
- interacts with JARID1A & JARID1B
Structure
contains 1 basic helix-loop-helix (bHLH) domain
Compartment
Expression
expressed during fetal development
Pathology
- defects in MYCN are the cause of Feingold syndrome
- defects in MYCN are the cause of microcephaly & digital abnormalities with normal intelligence
- amplification seen in neuroblastomas & other malignancies; amplification appears to increase as a tumor progresses
More general terms
References
- ↑ Dwarki VJ, Montminy M, Verma IM. Both the basic region and the 'leucine zipper' domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation. EMBO J. 1990 Jan;9(1):225-32. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2136830
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/NMYC112.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=MYCN
- ↑ UniProt http://www.uniprot.org/uniprot/P04198.html
Database
- UniProt: http://www.uniprot.org/uniprot/P04198.html
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4613
- OMIM: https://mirror.omim.org/entry/164280
- OMIM: https://mirror.omim.org/entry/164840
- OMIM: https://mirror.omim.org/entry/602585
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4613