retinoblastoma binding protein 2; histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; RBBP-2 (JARID1A, RBBP2, RBP2, KDM5A)

Function

• histone demethylase that specifically demethylates Lys-4 of histone H3, thereby playing a central role in histone code
• does not demethylate histone H3 Lys-9, H3 Lys-27, H3 Lys-36, H3 Lys-79 or H4 Lys-20
• demethylates trimethylated & dimethylated but not monomethylated H3 Lys-4
• may stimulate transcription mediated by nuclear receptors
• may be involved in transcriptional regulation of Hox proteins during cell differentiation
• may participate in transcriptional repression of cytokines such as CXCL12
• interacts with the viral protein-binding domain of RB1
• interacts with ESR1, MYC, MYCN & LMO2

Cofactor: Fe+2 (putative)

Structure

• belongs to the JARID1 histone demethylase family
• contains 1 ARID domain
• contains 1 JmjC domain
• contains 1 JmjN domain
• contains 3 PHD-type Zn+2 fingers

Compartment

nucleus, nucleolus

More general terms

• histone demethylase
• transcription factor (TF)
• retinoblastoma-binding protein
• zinc finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5927
• UniProt: http://www.uniprot.org/uniprot/P29375.html
• OMIM: https://mirror.omim.org/entry/180202
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5927