rhombotin-2; LIM domain only protein 2; cysteine-rich protein TTG-2; T-cell translocation protein 2 (LMO2, RBTN2, RBTNL1, RHOM2, TTG2)

Function

• acts with TAL1/SCL to regulate red blood cell development
• also acts with LDB1 to maintain erythroid precursors in an immature state
• interacts via its LIM domains with ELF2 & LBD1
• also interacts with basic helix-loop-helix protein TAL1/SCL & can assemble in a complex with LMO2 & TAL1/SCL (putative)
• interacts with BEX2 & KDM5A

Structure

• the second LIM Zn+2-binding domain interacts with KDM5A
• contains 2 LIM Zn+2-binding domains

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Pathology

• chromosomal translocation t(11;14)(p13;q11) involving LMO2 with TCRD may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL)

More general terms

• LIM domain protein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/P25791.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4005
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4005
• OMIM: https://mirror.omim.org/entry/180385