scl proto-oncogene protein; stem cell protein; T-cell leukemia/lymphoma-5 protein; T-cell acute lymphocytic leukemia-1 protein; TAL1 (SCL, TCL5)

Function

• may play role in hematopoietic differentiation
• positive regulator of erythroid differentiation
• efficient DNA binding requires dimerization with another bHLH protein
• forms heterodimers with TCF3
• binds to the LIM domain containing protein LMO2 & to DRG1
• can assemble in a complex with LDB1 & LMO2.
• component of a TAL1 complex composed at least of CBFA2T3, LDB1, TAL1 & TCF3 (putative)
• phosphorylated on serine residues. phosphorylation of Ser-122
• strongly stimulated by hypoxia (putative)
• ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122; ubiquitination targets the protein for rapid degradation via the ubiquitin system; process may be characteristic of microvascular endothelial cells, since not observed in large vessel endothelial cells (putative)

Structure

• helix-loop-helix domain is necessary & sufficient for interaction with DRG1
• contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus (putative)

Alternative splicing

• named isoforms=3
• splicing pattern is cell-lineage dependent

Expression

leukemic stem cell

Pathology

• implicated in the genesis of hematopoietic malignancies
• chromosomal translocation t(1;14)(p32;q11) involving TAL1 with T-cell receptor alpha chain (TCRA) gene may be a cause of acute lymphoblastic leukemia

More general terms

• basic helix loop helix (bHLH) family transcription factor
• transcription factor (TF)
• proto oncogene protein

Database

• UniProt: http://www.uniprot.org/uniprot/P17542.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6886
• OMIM: https://mirror.omim.org/entry/187040