hematologic malignancy (hematopoietic malignancy, hematologic cancer)
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Etiology
- alcohol may not be a risk factor
- may have protective effect
- relative risk: leukemia (0.51), multiple myeloma (0.52), non-Hodgkin lymphoma (0.65), Hodgkin's disease (0.71)
- may have protective effect
Genetics
- see more specifc types
- chromosomal deletion involving UHRF2 is found in multiple kinds of malignancies
- implicated genes (not otherwise specified) ROPN1
Management
- prophylactic platelet transfusion in patients with platelet counts <10,000/uL (<20,000/uL in febrile patients)[1]
Notes
- patients with hematologic malignancies often receive aggressive end-of-life care[3]
More general terms
More specific terms
- blastic plasmacytoid dendritic cell neoplasm (BPDCN)
- leukemia
- lymphoma (lymphosarcoma)
- myeloid sarcoma (extramedullary myeloid tumor, granulocytic sarcoma, chloroma)
References
- ↑ 1.0 1.1 Stanworth SJ et al. A no-prophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med 2013 May 9; 368:1771 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23656642
Slichter SJ. Eliminate prophylactic platelet transfusions? N Engl J Med 2013 May 9; 368:1837. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23656650 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1212772 http://www.nejm.org/doi/full/10.1056/NEJMe1302974 - ↑ Ji J, Sundquist J, Sundquist K. Neoplasia. 2014 Mar;16(3):229-234.e1. Alcohol Consumption Has a Protective Effect against Hematological Malignancies: a Population-Based Study in Sweden Including 420,489 Individuals with Alcohol Use Disorders. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24783999
- ↑ 3.0 3.1 Hui D et al. Quality of end-of-life care in patients with hematologic malignancies: A retrospective cohort study. Cancer 2014 May 15; 120:1572 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24549743
- ↑ Sanchez-Ramon S, Dhalla F, Chapel H. Challenges in the Role of Gammaglobulin Replacement Therapy and Vaccination Strategies for Hematological Malignancy. Front Immunol. 2016 Aug 22;7:317. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27597852 Free PMC Article