ropporin-1A (rhophilin-associated protein 1A, cancer/testis antigen 91, CT91, ROPN1 ROPN1A)

Function

• interacts with AKAP3 & RHPN1
• may interact with SPA17

Structure

• homodimer
• RIIa domain mediates interaction with AKAP3
• belongs to the ropporin family
• contains 1 RIIa domain

Compartment

• in the sperm tail, found in the principal piece & in the cytoplasmic droplet located at the distal end of the midpiece.

inner surface of the fibrous sheath

Alternative splicing

named isoforms=2

Expression

• testis specific in adult
• expressed in fetal liver

Pathology

• overexpressed in hematologic tumor cells

Notes

The name 'ropporin' comes from the Japanese word 'oppo' which means 'tail'

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9HAT0.html