A-kinase anchor protein 3; AKAP-3; A-kinase anchor protein 110 kD; AKAP 110; cancer/testis antigen 82; CT82; fibrous sheath protein of 95 kD; FSP95; fibrousheathin I; fibrousheathin-1; protein kinase A-anchoring protein 3; PRKA3; sperm oocyte-binding protein (AKAP3 AKAP110 SOB1)

Function

• may function as a regulator of both motility- & head- associated functions such as capacitation & the acrosome reaction
• phosphorylated on Tyr
• interacts with ROPN1 & ROPN1L

Structure

• PKA RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA-R-subunit dimer
• belongs to the AKAP110 family

Compartment

• cytoplasmic vesicle, secretory vesicle, acrosome (putative)
• ribs of the fibrous sheath in the principal piece of the sperm tail
• dorsal margin of the acrosomal segment

Expression

• testis specific
• only expressed in spermatids

More general terms

• A-kinase anchor protein
• myristoylated protein
• phosphoprotein
• testis-specific protein

Additional terms

• protein kinase A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10566
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10566
• OMIM: https://mirror.omim.org/entry/604689
• UniProt: http://www.uniprot.org/uniprot/O75969.html