protein kinase A

Classification

• 2 types: PKA1, PKA2

Function

• phosphorylates a large number of substrates in cytoplasm & nucleus
• a number of inactive tetrameric holoenzymes are produced by combination of homo- or heterodimers of different regulatory subunits associated with two catalytic subunits
• cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to 4 cAMP & 2 free monomeric catalytic subunits
• activated by cAMP

Compartment

• translocates into the nucleus (monomeric catalytic subunit)
• the inactive holoenzyme is found in the cytoplasm (putative)

Pharmacokinetics

• protein kinase A has a long, but unspecified 1/2life

More general terms

• serine/threonine kinase
• multisubunit protein
• allosteric enzyme

More specific terms

• protein kinase A1
• protein kinase A2

Additional terms

• glycogen storage disease type-X