protein kinase A2 [PKA2] regulatory subunit; AKAP5; A-kinase anchor protein 79; AKAP-79 (PKA2R)

Function

• PKA2 regulatory chains mediate membrane association by binding to anchoring proteins, including MAP2 kinase.
• inactive form of PKA2 consists of 2 PKA2 regulatory chains & 2 cAMP protein kinase (catalytic) chains
• activation by cAMP produces two active cAMP protein kinase monomers and a PKA2 regulatory chain dimer that binds 4 cAMP
• interacts with AKAP4
• phosphorylated by activated cAMP protein kinase

Compartment

• may be bound to endomembranes.

More general terms

• protein kinase A [PKA] regulatory subunit
• calmodulin binding protein
• PEST protein

More specific terms

• protein kinase A2 [PKA2] regulatory subunit-alpha (PRKAR2A)
• protein kinase A2 [PKA2] regulatory subunit-beta (PRKAR2B)

Component of

• protein kinase A2

Database

• UniProt: http://www.uniprot.org/uniprot/P24588.html
• OMIM: https://mirror.omim.org/entry/176910