non-Hodgkin's lymphoma

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Classification

Etiology

predisposing factors

Epidemiology

  • approximately 40,000 cases/year
  • average age of presentation early 40's
    • incidence of low-grade lymphomas increases with advanced age[5] {overall 35%}
  • majority of patients present with advanced disease
  • 10-20% present with disease outside of lymph nodes & spleen
  • more common in men[5]

Pathology

Immunohistochemistry:

Genetics

Clinical manifestations

Laboratory

Diagnostic procedures

Radiology

* essential for clinical staging

Staging

Complications

Management

* bleomycin, methotrexate, procarbazine, nitrogen mustard, cytosine arabinoside, etoposide.

More general terms

More specific terms

Additional terms

References

  1. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 1782, 1786
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 426-28
  3. 3.0 3.1 3.2 3.3 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, 16. American College of Physicians, Philadelphia 1998, 2006, 2009, 2012
  4. 4.0 4.1 Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 539
  5. 5.0 5.1 5.2 Schiller G, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  6. Ferri's Clinical Advisor, Instant Diagnosis and Treatment, Ferri FF (ed), Mosby, Philadelphia, 2003
  7. 7.0 7.1 Resvani AR et al, Nonmyeloablative allogeneic hematopoietic cell transplantation in relapses, refractory, and transformed indolent non-Hodgkin's lymphoma. J Clin Oncol 2008, 26:211 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18056679
  8. 8.0 8.1 Philip T, Guglielmi C, Hagenbeek A et al Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med. 1995 Dec 7;333(23):1540-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7477169
  9. 9.0 9.1 Deng J et al. Risk of hematologic cancer in patient with undifferentiated pruritis. JAMA Dermatol 2022 Jul; 158:791. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35612839 PMCID: PMC9134041 (available on 2023-05-25) https://jamanetwork.com/journals/jamadermatology/fullarticle/2792454
  10. 10.0 10.1 10.2 NEJM Knowledge+ Otolaryngology

Patient information

non Hodgkin's lymphoma patient information

Database